The biology of Toll-like receptors.
Cytokine Growth Factor Rev
; 11(3): 219-32, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-10817965
ABSTRACT
In 1997, a human homologue of the Drosophila Toll protein was described, a protein later to be designated Toll-like receptor 4 (TLR4). Since that time, additional human and murine TLR proteins have been identified. Mammalian TLR proteins appear to represent a conserved family of innate immune recognition receptors. These receptors are coupled to a signaling pathway that is conserved in mammals, insects, and plants, resulting in the activation of genes that mediate innate immune defenses. Numerous studies have now identified a wide variety of chemically-diverse bacterial products that serve as putative ligands for TLR proteins. More recent studies have identified the first endogenous protein ligands for TLR proteins. TLR signaling represents a key feature of innate immune response to pathogen invasion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Transdução de Sinais
/
Lipopolissacarídeos
/
Receptores de Superfície Celular
/
Proteínas de Drosophila
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
BIOQUIMICA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos