The effects of pentoxifylline on spinal cord blood flow after experimental spinal cord injury.
J Assoc Acad Minor Phys
; 10(1): 23-6, 1999.
Article
em En
| MEDLINE
| ID: mdl-10826005
ABSTRACT
Previous clinical and experimental investigations have suggested that pentoxifylline, a methylxanthine, can improve cerebrovascular circulation and reduce cerebral edema in cerebrovascular disorders. Pentoxifylline's mechanism of action includes such rheologic effects as enhanced red cell deformability, alterations in leukocyte activation, and modification of coagulation parameters. The purpose of our investigation was to determine the effects of pentoxifylline in an experimental spinal cord injury model. A compression device was used to cause a reproducible spinal cord injury in adult female albino rats. Spinal cord blood flow was monitored using a laser Doppler flow meter pre- and postinjury for 4 hours. The experimental group (N = 7) was injected with pentoxifylline 10 minutes prior to injury. The control group (N = 5) received an identical protocol, except that this group was injected with an equal amount of saline. Results of this investigation revealed that pentoxifylline treatment significantly increased spinal cord blood flow. In the pentoxifylline-treated group, spinal cord blood flow was significantly higher from 120 to 240 minutes postinjury compared with that of the control group. We conclude that via its multiple physiologic effects, pentoxifylline significantly improves spinal cord blood flow in experimental spinal cord injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pentoxifilina
/
Medula Espinal
/
Traumatismos da Medula Espinal
/
Fármacos Hematológicos
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Revista:
J Assoc Acad Minor Phys
Assunto da revista:
MEDICINA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos