Effects of pinostrobin on estrogen metabolism and estrogen receptor transactivation.
Cancer Lett
; 156(1): 37-44, 2000 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-10840157
ABSTRACT
The interaction between the estrogen receptor and 5-hydroxy-7-methoxyflavanone (pinostrobin) was studied in the presence or absence of estradiol or dehydroepiandrosterone sulfate (DHEAS), respectively, using a stably transfected human breast cancer cell line (MVLN). We also evaluated its action on the proliferation in estrogen-dependent (MCF-7) human breast cancer cells in the same conditions than the estrogen receptor assay. On the other hand pinostrobin was evaluated for their effects on the human placental aromatase, 3beta-hydroxysteroid dehydrogenase Delta(4)/Delta(5) isomerase and 17beta-hydroxysteroid dehydrogenase activities. Pinostrobin did not possess antiestrogenic activity but presented anti-aromatase activity and decreased the growth of MCF-7 cells induced by DHEAS and E(2). This study provides particularly evidence of the potential biological interest of pinostrobin among the flavonoids.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Receptores de Estrogênio
/
Ativação Transcricional
/
Flavanonas
/
Estrogênios
/
Antineoplásicos Fitogênicos
Limite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
França