NMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus.
J Control Release
; 68(1): 73-83, 2000 Jul 31.
Article
em En
| MEDLINE
| ID: mdl-10884581
ABSTRACT
A system for performing NMR imaging experiments on drug delivery devices within a flow-through dissolution apparatus, USP Apparatus 4, has been developed. The system was used to image the physical changes that occur in solid dosage forms during dissolution in the flow-through apparatus. Simultaneous cumulative drug release measurements were also made. The NMR images obtained under these conditions and the drug release data provide a better understanding of the processes involved in the release of drugs from drug delivery systems based on diffusion, dissolution and osmosis mechanisms.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espectroscopia de Ressonância Magnética
/
Sistemas de Liberação de Medicamentos
/
Lactose
/
Metilcelulose
Idioma:
En
Revista:
J Control Release
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Canadá