A novel member of the RING-finger gene family associated with reproductive tissues of the mosquito, Aaedes aegypti.
Insect Mol Biol
; 9(3): 301-8, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10886414
ABSTRACT
The RING finger is a zinc-binding domain that is found in proteins from viruses, plants and animals. Here we report the characterization and tissue-specific expression of a mosquito gonadal protein gene, mgp, from the mosquito, Aedes aegypti. The putative gene product, MGP, contains two RING fingers, a B-box, and a hydrophobic core. These mosquito MGP structural motifs are highly conserved in proteins found in mouse and nematode. Northern blot analysis and in situ hybridization demonstrated the presence of multiple mgp RNA transcripts in male and female reproductive tissues. Expression of mgp in the ovary is constitutive, but an increase in message was observed in the ovaries of female mosquitoes previously exposed to a blood meal. These results suggest that MGP is a protein that might play a role(s) in mosquito gametogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dedos de Zinco
/
Genes de Insetos
/
Proteínas de Insetos
/
Aedes
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Insect Mol Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos