Synthesis and anti-aggregatory activity of linear retro-inverso RGD peptides.
J Pept Res
; 55(6): 447-54, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10888201
ABSTRACT
Six retro-inverso tri- and tetrapeptide analogues of RGD were prepared and their anti-aggregatory activity was determined by platelet aggregation tests in comparison with the corresponding parent peptides. An efficient method for the introduction of a malonyl-aspartic residue into a peptide chain is described for the first time. A 2-3-fold decrease in potency or total loss of bioactivity was observed with the new peptides; structure-activity relationships are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Inibidores da Agregação Plaquetária
Limite:
Humans
Idioma:
En
Revista:
J Pept Res
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Itália