Theoretical analysis of a rectifying gap junction model.
Methods Inf Med
; 39(2): 150-2, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10892251
ABSTRACT
Based on the experimental observations, an electrical circuitry model for a rectifying gap junction was developed in previous work. In order to show the physiological function for each element in the model, a theoretical analysis is carried out in this report. The results indicate that the gap junctional capacitance Cj newly introduced into the model plays a major role in determining the duration increase, the peak attenuation, and the peak delay on the postmembrane action potential. Also, a comparison between the newly proposed model and the widely accepted kinetic model by Giaume is made. The results show that the electrical circuitry model can not only describe the characteristics of Giaume's model but also allow the interpretation of some experimental phenomena that were not reflected in other gap junctional models.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Processamento de Sinais Assistido por Computador
/
Junções Comunicantes
/
Transmissão Sináptica
/
Modelos Neurológicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Methods Inf Med
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Hong Kong