Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography.
Life Sci
; 66(25): 2455-64, 2000.
Article
em En
| MEDLINE
| ID: mdl-10894088
ABSTRACT
Using positron emission tomography (PET) and [11C]N-methylspiperone (NMSP), we examined 5-HT2 receptors in the cortex of schizophrenic patients in whom we previously observed decreased prefrontal D1 receptor binding. The subjects were 10 neuroleptic-naive schizophrenic patients, 7 schizophrenic patients who were drug-free but had previously been treated with neuroleptics, and 12 normal controls. A non-significant trend towards decreased prefrontal [11C]NMSP binding was observed in the neuroleptic-treated patients, suggesting a possible effect of previous neuroleptic treatment on the alteration in cortical 5-HT2 function. However, the neuroleptic-naive patients showed no noticeable difference in cortical [11C]NMSP binding compared to controls. Our results do not rule out the role of 5-HT2 function as a crucial site of therapeutic activity of schizophrenia, but they do suggest that cortical 5-HT2 receptors might not be primarily involved in the pathophysiology of schizophrenia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Espiperona
/
Córtex Cerebral
/
Receptores de Serotonina
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Japão