Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease.
J Neuroimmunol
; 108(1-2): 227-35, 2000 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-10900358
ABSTRACT
Inflammatory mediators have been implicated in the pathophysiology of neurodegenerative diseases. Here we report the presence of the chemokine receptor CXCR3 and its ligand, IP-10, in normal and Alzheimer's disease (AD) brains. CXCR3 was detected constitutively on neurons and neuronal processes in various cortical and subcortical regions; IP-10 was observed in a subpopulation of astrocytes in normal brain, and was markedly elevated in astrocytes in AD brains. Many IP-10(+) astrocytes were associated with senile plaques and had an apparently coordinated upregulation of MIP-1beta. Moreover, we showed that CXCR3 ligands, IP-10 and Mig, were able to activate ERK1/2 pathway in mouse cortical neurons, suggesting a novel mechanism of neuronal-glial interaction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Astrócitos
/
Receptores de Quimiocinas
/
Quimiocinas CXC
/
Proteínas Quinases Ativadas por Mitógeno
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Peptídeos e Proteínas de Sinalização Intercelular
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Doença de Alzheimer
/
Neurônios
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos