DNA damage-induced mutation: tolerance via translesion synthesis.
Mutat Res
; 451(1-2): 169-85, 2000 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-10915871
ABSTRACT
Translesion synthesis (TLS) appears to be required for most damage-induced mutagenesis in the yeast Saccharomyces cerevisiae, whether the damage arises from endogenous or exogenous sources. Thus, the production of such mutations seems to occur primarily as a consequence of the tolerance of DNA lesions rather than an error-prone repair mechanism. Tolerance via TLS in yeast involves proteins encoded by members of the RAD6 epistasis group for the repair of ultraviolet (UV) photoproducts, in particular two non-essential DNA polymerases that catalyse error-free or error-prone TLS. Homologues of these RAD6 group proteins have recently been discovered in rodent and/or human cells. Furthermore, the operation of error-free TLS in humans has been linked to a reduced risk of UV-induced skin cancer, whereas mutations generated by error-prone TLS may increase the risk of cancer. In this article, we review and link the evidence for translesion synthesis in yeast, and the involvement of nonreplicative DNA polymerases, to recent findings in mammalian cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Proteínas de Saccharomyces cerevisiae
/
Reparo do DNA
/
Mutação
Limite:
Humans
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Austrália