Bronchoalveolar lavage macrophage-lymphocyte clusters in granulomatous disease are linked to lymphocytosis.
Sarcoidosis Vasc Diffuse Lung Dis
; 17(2): 174-80, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10957766
ABSTRACT
BACKGROUND AND AIM OF THE WORK Clusters of macrophages associated with lymphocytes (ML clusters) have been observed among the bronchoalveolar lavage (BAL) cells of patients with pulmonary disease. We tested the hypothesis that ML clusters might be found among the BAL cells from patients with granulomatous disease. METHODS:
We measured the number of ML clusters among the BAL cells from normal controls (n = 13), sarcoidosis patients (n = 18), beryllium-sensitized (BeS) patients (n = 21) and chronic beryllium disease (CBD) patients (n = 15).RESULTS:
ML clusters were observed in the BAL cells of all groups, but at different frequencies normal 8.5% (median, range 2-15%); BeS 7% (range 2-31%); sarcoidosis 14% (range 4-50%); and CBD 17% (range 6-73%). This data suggested that ML clusters were increased in granulomatous lung disease. However, the percentage of ML clusters strongly correlated with the BAL lymphocyte percentage (rho = 0.79). Cohort analysis showed that increases in macrophages having 2, 3 or > 3 associated lymphocytes correlated with an increase in lymphocyte percentage.CONCLUSIONS:
An increase in ML clusters in BAL cells is not specific for granulomatous disease and is associated with the increase in BAL lymphocytes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Beriliose
/
Linfócitos
/
Macrófagos Alveolares
/
Sarcoidose Pulmonar
/
Doença Granulomatosa Crônica
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Sarcoidosis Vasc Diffuse Lung Dis
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
ANGIOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos