TNF-alpha activates solitary nucleus neurons responsive to gastric distension.
Am J Physiol Gastrointest Liver Physiol
; 279(3): G582-6, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-10960358
ABSTRACT
Tumor necrosis factor-alpha (TNF-alpha) is liberated as part of the immune response to antigenic challenge, carcinogenesis, and radiation therapy. Previous studies have implicated elevated circulating levels of this cytokine in the gastric hypomotility associated with these disease states. Our earlier studies suggest that a site of action of TNF-alpha may be within the medullary dorsal vagal complex. In this study, we describe the role of TNF-alpha as a neuromodulator affecting neurons in the nucleus of the solitary tract that are involved in vago-vagal reflex control of gastric motility. The results presented herein suggest that TNF-alpha may induce a persistent gastric stasis by functioning as a hormone that modulates intrinsic vago-vagal reflex pathways during illness.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estômago
/
Dilatação Gástrica
/
Fator de Necrose Tumoral alfa
/
Núcleo Solitário
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Am J Physiol Gastrointest Liver Physiol
Assunto da revista:
FISIOLOGIA
/
GASTROENTEROLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos