Endogenous and ectopic gland induction by FGF-10.
Dev Biol
; 225(1): 188-200, 2000 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-10964474
ABSTRACT
FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Crescimento de Fibroblastos
/
Glândula de Harder
Limite:
Animals
Idioma:
En
Revista:
Dev Biol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos