Effect of cyclic GABA derivative TZ-146 on the content of neurotransmitters in rat brain stem.
Bull Exp Biol Med
; 129(5): 460-2, 2000 May.
Article
em En
| MEDLINE
| ID: mdl-10977951
ABSTRACT
The effect of cyclic GABA derivative TZ-146 on the content of catecholamines, serotonin, their metabolites, and neurotransmitter amino acids in rat hypothalamus and brain stem was studied by high-performance liquid chromatography with electrochemical detection. Opposite changes in the content of homovanillic acid, aspartate, glutamate, and glycine in the examined structures were accompanied by inhibition of dopamine metabolism. Possible participation of cerebral glutamatergic system in the effect of TZ-146 is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tronco Encefálico
/
Neurotransmissores
/
Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2000
Tipo de documento:
Article