Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats.
Brain Res
; 878(1-2): 223-7, 2000 Sep 29.
Article
em En
| MEDLINE
| ID: mdl-10996157
ABSTRACT
We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Plantas
/
Acetilcolinesterase
/
Imunotoxinas
/
Prosencéfalo
/
Epilepsia Generalizada
/
Convulsivantes
/
Neurônios
/
N-Glicosil Hidrolases
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos