Molecular events implicated in brain tumor angiogenesis and invasion.
Pediatr Neurosurg
; 33(1): 49-55, 2000 Jul.
Article
em En
| MEDLINE
| ID: mdl-11025423
ABSTRACT
We have conducted studies designed to help elucidate the molecular mechanisms involved in brain tumor invasion and angiogenesis, which are critical in the growth of malignant tumors of the central nervous system. A variety of molecular factors have been implicated in these processes. Here we focus on three that are of particular importance in the progression of brain tumors. Angiopoietins are involved in the regulation of vascular development. Hypoxia inducible factor-1 is a transcription factor that up-regulates genes, including genes encoding vascular endothelial growth factor under hypoxic conditions. Focal adhesion kinase is associated with infiltration of tumor cells and angiogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Neoplasias Encefálicas
/
Proteínas Tirosina Quinases
/
Proteínas Nucleares
/
Fatores de Crescimento Endotelial
/
Proteínas de Ligação a DNA
/
Glioma
/
Neovascularização Patológica
Limite:
Humans
Idioma:
En
Revista:
Pediatr Neurosurg
Assunto da revista:
NEUROCIRURGIA
/
PEDIATRIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos