Pilocarpine in the prevention of postirradiation xerostomia.
Acta Med Croatica
; 54(2): 65-7, 2000.
Article
em En
| MEDLINE
| ID: mdl-11028111
ABSTRACT
During radiation therapy to the head and neck region, salivary gland hypofunction commonly develops. The aim of our study was to evaluate whether the sialogogue pilocarpine given during radiation therapy may reduce the severity of xerostomia and salivary dysfunction. Our results showed the pilocarpine-treated group to have a lower frequency of oral symptoms during the treatment than the placebo-treated group. Although salivary flow decreased in all patients, the pilocarpine-treated group had smaller flow reductions. No drug effect was observed in the glands that were completely irradiated. Thus, pilocarpine appeared to stimulate salivary tissues outside the radiation field.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pilocarpina
/
Radioterapia
/
Xerostomia
/
Agonistas Muscarínicos
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Acta Med Croatica
Assunto da revista:
MEDICINA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Croácia