RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus.
Antimicrob Agents Chemother
; 44(11): 3163-6, 2000 Nov.
Article
em En
| MEDLINE
| ID: mdl-11036042
ABSTRACT
A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase beta-subunit (rpoB) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, and ripostatin A retained activity against the rpoB mutants. The second group of inhibitors may be of interest as drug development candidates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rifampina
/
Staphylococcus aureus
/
RNA Polimerases Dirigidas por DNA
/
Inibidores Enzimáticos
/
Lactamas
/
Antibacterianos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Reino Unido