Signature-tagged mutagenesis in the identification of virulence genes in pathogens.
Curr Opin Microbiol
; 3(5): 451-8, 2000 Oct.
Article
em En
| MEDLINE
| ID: mdl-11050441
ABSTRACT
Signature-tagged mutagenesis is a functional genomics technique that identifies microbial genes required for infection within an animal host, or within host cells. The application of this technique to a range of microbial pathogens has resulted in the identification of novel virulence determinants in each screen performed to date, so that cumulatively several hundred genes have been ascribed a role in virulence.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Virulência
/
Mutagênese Insercional
/
Genômica
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Curr Opin Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Reino Unido