Pharmacokinetics of a parenteral carbapenem, biapenem, in patients with end-stage renal disease and influence of haemodialysis.
J Antimicrob Chemother
; 46(5): 839-42, 2000 Nov.
Article
em En
| MEDLINE
| ID: mdl-11062211
ABSTRACT
The effects of haemodialysis on the pharmacokinetics of a carbapenem, biapenem, were evaluated in five patients with end-stage renal disease, who received 1 h iv infusions of 300 mg biapenem on both the days on and off 4 h haemodialysis. With haemodialysis, plasma biapenem exhibited two elimination phases, one during and the other after haemodialysis with half-lives of 1.16 +/- 0.12 and 3.33 +/- 0. 91 h, respectively. Ninety percent of biapenem was removed from blood to dialysate. Without haemodialysis, plasma biapenem was mono-exponentially eliminated with a half-life of 4.35 +/- 1.30 h.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tienamicinas
/
Diálise Renal
/
Falência Renal Crônica
/
Anti-Infecciosos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Japão