Single cause, polymorphic neuronal migration disorders: an animal model.
Dev Med Child Neurol
; 42(10): 652-62, 2000 Oct.
Article
em En
| MEDLINE
| ID: mdl-11085292
ABSTRACT
Injury to the developing cortical plate can result in a variety of neuronal migration disorders. The results are reported of experimental research aimed at determining whether these different types of neocortical malformations are the consequence of comparable injury of varying intensity. Freezing probes were placed on the skulls of 44 newborn rats (age equivalent to 4 to 5 months of gestation in humans) and induced either one or two freezing injuries of durations ranging from 2 to 20 seconds. A variety of cortical malformations including minor laminar dysplasias, molecular layer ectopias, microgyria, and porencephalic cysts were seen in the brains of these animals when they were examined on postnatal day (P)2, P21, and P60. The severity of the malformation was directly related to the strength (number of hits and duration) of the freezing injury. These results suggest that a single etiologic event of varying severity during neuronal migration to the neocortex can induce widely disparate malformations of the cortex.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Córtex Cerebral
/
Neurônios
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Dev Med Child Neurol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos