Biological selection of variant-specific surface proteins in Giardia lamblia.
J Infect Dis
; 183(1): 119-24, 2001 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-11087204
ABSTRACT
Immune evasion is frequently cited as the main reason for antigenic variation in pathogenic microorganisms. To better understand the role of switching of variant-specific surface proteins (VSPs) in Giardia lamblia-host interactions, antigenic variation during infections of mice and gerbils was examined, using clones that predominantly expressed unique VSPs. As expected, VSPs were selected against during infections of immunocompetent hosts. In contrast, in immunodeficient hosts, some VSPs were selected for and others were selected against. These diverse patterns of selection demonstrate that there are host-VSP interactions that exert both positive and negative selective pressures on parasites, independent of the adaptive immune response. Furthermore, selection was dependent on both the particular VSP and the host. Thus, the large number of VSP genes in G. lamblia may allow the parasite to infect multiple different hosts, and antigenic variation could be a mechanism to expand the parasite's host range.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Giardíase
/
Giardia lamblia
/
Antígenos de Protozoários
/
Antígenos de Superfície
Limite:
Animals
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos