Gene expression of GLUT isoforms and VHL in oral squamous cell carcinoma.
Cancer Lett
; 161(2): 133-40, 2000 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-11090961
ABSTRACT
In human oral squamous cell carcinoma (OSCC) cell lines, we detected atypical mRNA expression of GLUT2 and/or GLUT4 in addition to enhanced expression of GLUT1 mRNA using RT-PCR. In semi-quantitative reverse transcription-polymerase chain reaction analysis of mRNA expression in OSCC cell lines, we found an inverse relationship between mRNA expression of von Hippel-Lindau (VHL) and that of GLUT1, with no apparent influence on the expression of other GLUTs. These findings suggest that the reduction of VHL may play a critical role in glucose uptake of OSCC cell lines, with enhancement of GLUT1 expression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte de Monossacarídeos
/
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Proteínas
/
Proteínas Supressoras de Tumor
/
Ubiquitina-Proteína Ligases
/
Ligases
/
Proteínas Musculares
/
Proteínas do Tecido Nervoso
Limite:
Humans
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Japão