2,3-Butanedione monoxime suppresses primarily total calcium handling in canine heart.
Jpn J Physiol
; 50(5): 543-51, 2000 Oct.
Article
em En
| MEDLINE
| ID: mdl-11120921
ABSTRACT
Whether 2,3-butanedione monoxime (BDM, < or = 5mmol/l) suppresses primarily crossbridge cycling or total Ca(2+) handling in the blood-perfused whole heart remains controversial. Although BDM seems to suppress primarily total Ca(2+) handling in canine hearts, more evidence is lacking. We therefore analyzed the cardiac mechanoenergetics, namely, E(max) (contractility), PVA (total mechanical energy), and O(2) consumption of canine BDM-treated hearts by our recently developed integrative method to assess myocardial total Ca(2+) handling. This method additionally required the internal Ca(2+) recirculation fraction. We obtained this from the beat constant of the exponential decay component of the postextrasystolic potentiation. Our analysis indicated significant decreases in both internal Ca(2+) recirculation fraction and total Ca(2+) handling in the BDM-treated heart, but virtually no change in the reactivity of E(max) to total Ca(2+) handling. This result corroborates the view that BDM suppresses primarily total Ca(2+) handling rather than crossbridge cycling in the canine blood-perfused heart.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
Diacetil
/
Inibidores Enzimáticos
/
Contração Miocárdica
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Jpn J Physiol
Ano de publicação:
2000
Tipo de documento:
Article