Using the number of koilocytes to predict HIV serostatus in women with HPV-associated SIL.
Acta Cytol
; 44(6): 1000-4, 2000.
Article
em En
| MEDLINE
| ID: mdl-11127727
ABSTRACT
OBJECTIVE:
To investigate the relationship between specific cytopathologic changes, koilocyte counts and human papillomavirus (HPV) types in HIV-positive and -negative women. STUDYDESIGN:
A cohort of 459 women (266 HIV+ and 193 HIV-), were examined in a multicentric study (Early Diagnosis of Neoplasia in AIDS) involving 14 gynecologic centers. Altogether, 97 women had cervical smears consistent with squamous intraepithelial lesions (SIL). Koilocytes were found in 60/97 SIL slides, subjected to quantitative counting in 30 predetermined fields. HPV genotype was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis.RESULTS:
SIL lesions were four times more frequent (29%) in HIV-positive women than in HIV-negative women (10%) (odds ratio = 3.80). HPV DNA was equally frequent in both groups. There was a strong association between the number of koilocytes and HIV serostatus in both high grade and low grade SIL diagnoses. The presence of eight or more koilocytes had a specificity of 93% and sensitivity of 76% toward the diagnosis of HIV-positive status. No HIV-negative woman had a count > 8 koilocytes. No association was shown between koilocyte count and HPV genotype.CONCLUSION:
An elevated number of koilocytes could suggest the possibility of HIV infection. Pap smear examination might give the first clue to HIV positivity in otherwise-unsuspected cases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Infecções Tumorais por Vírus
/
Esfregaço Vaginal
/
Carcinoma in Situ
/
Carcinoma de Células Escamosas
/
Neoplasias do Colo do Útero
/
Soropositividade para HIV
/
Infecções por Papillomavirus
/
Teste de Papanicolaou
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Acta Cytol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Itália