Normal tissue radiobiology: from the laboratory to the clinic.
Int J Radiat Oncol Biol Phys
; 49(2): 353-65, 2001 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-11173128
ABSTRACT
This manuscript is in four parts, presenting the four talks given in a symposium on normal tissue radiobiology. The first part addresses the general concept of the role of parenchymal cell radiosensitivity vs. other factors, highlighting research over the last decade that has altered our understanding of factors underlying normal tissue response. The other three parts expand on specific themes raised in the first part dealing in particular with (1) modifications of fibroblast response to irradiation in relation to the induction of tissue fibrosis, (2) the use of the linear-quadratic equation to model the potential benefits of using different means (both physical and biologic) of modifying normal tissue response, and (3) the specific role of the growth factor TFG-beta1 in normal tissue response to irradiation. The symposium highlights the complexities of the radiobiology of late normal tissue responses, yet provides evidence and ideas about how the clinical problem of such responses may be modified or alleviated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tolerância a Radiação
/
Radiobiologia
/
Fator de Crescimento Transformador beta
/
Difusão de Inovações
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Sysrev_observational_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Radiat Oncol Biol Phys
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Canadá