Solid low-grade in situ carcinoma of the breast: role of associated lesions and E-cadherin in differential diagnosis.
Am J Surg Pathol
; 25(2): 237-44, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11176073
ABSTRACT
Low-grade solid in situ carcinomas of the breast are difficult to classify. The authors investigated 12 cases of in situ carcinomas with equivocal features and correlated their histologic attributes with those of the associated invasive carcinomas as well as with E-cadherin expression in both in situ and invasive disease. E-cadherin-positive in situ lesions were invariably associated with invasive carcinomas of the ductal type. In situ carcinomas that were E-cadherin negative were associated with invasive carcinomas of the lobular type in five of six cases. In all cases, the invasive carcinomas showed the same pattern of E-cadherin reactivity as the in situ lesions. Sharply defined cellular membranes, necrosis, and occasional microacini were seen in both E-cadherin-positive and negative in situ carcinomas, whereas intracytoplasmic lumina and a noncohesive appearance were seen only in E-cadherin-negative lesions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Carcinoma in Situ
/
Caderinas
/
Carcinoma Lobular
/
Carcinoma Ductal de Mama
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Am J Surg Pathol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos