The genome-wide distribution of background linkage disequilibrium in a population isolate.
Hum Mol Genet
; 10(5): 545-51, 2001 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-11181579
ABSTRACT
Recent interest in using association studies to investigate complex traits has focused attention on understanding linkage disequilibrium (LD) in the human genome. We examined the genome-wide distribution and magnitude of such background LD (BLD) using 1036 densely spaced microsatellites, in a sample from the demographically well characterized population of the Central Valley of Costa Rica. High levels of BLD were found between linked markers several centiMorgans apart, and although BLD was significantly related to genetic distance between markers it was not spread uniformly throughout the genome. Understanding the forces governing the distribution of BLD in the genome will require similar investigations using a standard set of markers in other populations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genoma Humano
/
Desequilíbrio de Ligação
/
Genética Populacional
Limite:
Humans
Idioma:
En
Revista:
Hum Mol Genet
Assunto da revista:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos