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Real-time sonography for screening of gallbladder dysfunction in children with type 1 diabetes mellitus.
Arslanoglu, I; Unal, F; Sagin, F; Isgüven, P; Isik, K.
Afiliação
  • Arslanoglu I; Department of Pediatrics, Göztepe Educational Hospital of SSK, Turkey.
J Pediatr Endocrinol Metab ; 14(1): 61-9, 2001 Jan.
Article em En | MEDLINE | ID: mdl-11220707
ABSTRACT
The aim of this study was to evaluate the occurrence of gallbladder dysfunction in children with type 1 diabetes mellitus using real-time ultrasonography. The study population consisted of 20 diabetic children (11 male, 9 female; age 11.7+/-2.8 years; diabetes duration 0.5-7 years) with clinically negative neuropathy findings and 15 healthy controls (11 male, 4 female; age 10.5+/-3.7 years). Three-dimensional measurements of the gallbladder were made before and 15, 30, 45, 60 min after intake of diet chocolate. Gallbladder volumes were calculated by the ellipsoid formula. Fasting gallbladder volume of diabetic children (16.9+/-9.5 ml) was significantly greater than that of the controls (10.6+/-5.3 ml; p=0.017). Ejection fraction and maximal contraction showed no significant difference between the two groups. Diabetic patients with multiple microvascular complications had diminished gallbladder motility. There was a negative correlation between BMI and maximal contraction (p<0.05). Nerve conduction velocity was diminished in 45% of the diabetic patients. In conclusion, gallbladder function is preserved in pediatric type 1 diabetic patients with a disease duration less then 10 years, but dilated gallbladder at rest may be an early sign of gastrointestinal autonomic neuropathy and a risk factor for gallstone formation.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 / Doenças da Vesícula Biliar Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Pediatr Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / PEDIATRIA Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Turquia
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 1 / Doenças da Vesícula Biliar Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Pediatr Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / PEDIATRIA Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Turquia