Interference with the formation of the epididymal microenvironment--a new strategy for male contraception?
Asian J Androl
; 2(1): 39-45, 2000 Mar.
Article
em En
| MEDLINE
| ID: mdl-11228936
ABSTRACT
The cystic fibrosis transmembrane conductance regulator (CFTR) or the small conductance cAMP-activated chloride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epididymal fluid microenvironment. Recent work in our laboratory has shown that this protein is also expressed by developing germ cells indicating a role of this protein in spermatogenesis. In view of the fact that the CFTR gene has a far reaching and widespread effect on human reproduction, understanding the role of CFTR in the male reproductive tissues and its intervention by pharmacological agents can open a new avenue of research into the development of novel male contraceptives.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anticoncepção
/
Epididimo
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Asian J Androl
Assunto da revista:
MEDICINA REPRODUTIVA
/
UROLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
China