A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation.
J Pharm Biomed Anal
; 24(5-6): 871-6, 2001 Mar.
Article
em En
| MEDLINE
| ID: mdl-11248480
ABSTRACT
The inclusion complex formation between Metoprolol tartarata (MeT) and beta-cyclodextrin (beta-CD) has been investigated using hyperchromic shift at lambda(max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH values 4.0 and 8.0 were established for optimal inclusion complex formation and confirmed two stoichiometric compositions 11 and 12. Preliminary data on usage of MeT/beta-CD complex in reversed-phase HPLC indicate the potential application of this complex as a kind of pre-column derivatization for enantiomeric separation of beta(1)-blockers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclodextrinas
/
Beta-Ciclodextrinas
/
Metoprolol
Idioma:
En
Revista:
J Pharm Biomed Anal
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Iugoslávia