The application of dimethyldioxirane for the selective oxidation of polyfunctional steroids.
Chem Phys Lipids
; 109(2): 135-43, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11269933
ABSTRACT
Oxidation and epoxidation reactions of a series of structurally different steroids related to methyl 5 beta-cholanoates having hydroxyl groups and/or double bonds by treatment with dimethyldioxirane (DMDO) are described. Steroidal alcohols, olefines, and unsaturated alcohols and conjugated enones with DMDO were transformed into ketones, epoxides, and epoxy-ketones, respectively, in good isolated yields. The regio- and stereoselectivities for DMDO reaction differing from those observed for organic peracids, tert-butyl hydroperoxide and alkaline hydrogen peroxide are also discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esteroides
/
Compostos de Epóxi
Idioma:
En
Revista:
Chem Phys Lipids
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão