The role of hepatocytes in the clearance of liposomes from the blood circulation.
Prog Lipid Res
; 40(3): 149-66, 2001 May.
Article
em En
| MEDLINE
| ID: mdl-11275265
ABSTRACT
In this chapter we summarize literature and describe in more detail our own observations over a period of nearly two decennia on the role of hepatocytes in the hepatic clearance of intravenously administered liposomes. Evidence is presented indicating that, although size is an important parameter, it is not decisive in determining access of liposomes to the hepatocytes. Also lipid composition is an important parameter, including charge, rigidity and headgroup composition. The role of the fenestrated sinusoidal endothelial cells in determining liposome accessibility of hepatocytes is discussed as well as the involvement of opsonizing plasma proteins such as apolipoprotein E. Our observations led us to postulate the existence of at least four different mechanisms of interaction of liposomes with hepatocytes, i.e. an endocytic and a non-endocytic one for both neutral and negatively charged vesicles
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hepatócitos
/
Lipossomos
Limite:
Humans
Idioma:
En
Revista:
Prog Lipid Res
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Holanda