Lack of tyrosine protein kinase regulation of L-type Ca2+ channel current in transfected cells stably expressing alpha1C-b Subunit.
Jpn J Physiol
; 51(1): 115-9, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11282003
ABSTRACT
Tyrosine protein kinase (Tyr-PK) regulation of L-type Ca2+ channel (CaL) current was studied in COS-7 cells expressing vascular smooth muscle-type alpha1C-b with no auxiliary subunit by using a whole-cell voltage clamp. The averaged peak amplitude of CaL currents was -0.33 +/- 0.03 at holding potential of -60 mV. Na(3)VO(4), genistein and phosphorylated p60(c-src) peptide had no effect on the current. Thus the alpha1C-b subunit may not be involved in Tyr-PK regulation of CaL current.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Canais de Cálcio Tipo L
Limite:
Animals
Idioma:
En
Revista:
Jpn J Physiol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos