Protective CD8+ T cell responses against the pre-erythrocytic stages of malaria parasites: an overview.
Mem Inst Oswaldo Cruz
; 96(2): 221-7, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11285500
ABSTRACT
CD8+ T cells have been implicated as critical effector cells in protection against the pre-erythrocytic stage of malaria in mice and humans following irradiated sporozoite immunization. Immunization experiments in animal models by several investigators have suggested different strategies for vaccination against malaria and many of the targets from liver stage malaria antigens have been shown to be immunogenic and to protect mice from the sporozoite challenge. Several prime/boost protocols with replicating vectors, such as vaccinia/influenza, with non-replicating vectors, such as recombinant particles derived from yeast transposon (Ty-particles) and modified vaccinia virus Ankara, and DNA, significantly enhanced CD8+ T cell immunogenicity and also the protective efficacy against the circumsporosoite protein of Plasmodium berghei and P. yeti. Based on these experimental results the development of a CD8+ T cell inducing vaccine has moved forward from epitope identification to planning stages of safety and immunogenicity trials of candidate vaccines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium
/
Malária Falciparum
/
Linfócitos T CD8-Positivos
/
Eritrócitos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Brasil