Interleukin-6 (IL-6) producing phaeochromocytoma: direct IL-6 suppression by non-steroidal anti-inflammatory drugs.
Clin Endocrinol (Oxf)
; 54(3): 405-10, 2001 Mar.
Article
em En
| MEDLINE
| ID: mdl-11298095
ABSTRACT
A 35-year-old Japanese woman presented with a phaeochromocytoma and demonstrated marked inflammatory reactions and pyrexia as a result of excessive production of interleukin-6 (IL-6) by the tumour. Serum IL-6 level was 262 ng/l (normal; < 4.0 ng/l). Fever and inflammatory markers were largely overcome by the administration of the nonsteroidal anti-inflammatory drug, naproxen, and all symptoms disappeared soon after the tumour was excised. Immunohistochemical study revealed positive staining using an antihuman IL-6 antibody and Northern analysis showed increased IL-6 mRNA levels in the tumour. Cultured tumour cells showed IL-6 protein synthesis, and nonsteroidal anti-inflammatory drugs such as naproxen and indomethacin directly inhibited IL-6 release. These results indicate that the effects of naproxen in vivo were due, at least in part, to direct suppression of IL-6 secretion from the tumour.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Feocromocitoma
/
Anti-Inflamatórios não Esteroides
/
Naproxeno
/
Interleucina-6
/
Neoplasias das Glândulas Suprarrenais
/
Proteínas de Neoplasias
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão