Anti-genotoxicity of trans-anethole and eugenol in mice.
Food Chem Toxicol
; 39(5): 493-8, 2001 May.
Article
em En
| MEDLINE
| ID: mdl-11313116
The naturally occurring flavouring agents trans-anethole and eugenol were evaluated for antigenotoxic effects in mice. The test doses of trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg weight) were administered by gavage 2 and 20 h before the genotoxins were injected intraperitoneally. Anti-genotoxic effects were assessed in the mouse bone marrow micronucleus test. Pretreatment with trans-anethole and eugenol led to significant antigenotoxic effects against cyclophosphamide (CPH), procarbazine (PCB), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and urethane (URE). In addition, trans-anethole inhibited the genotoxicity of ethyl methane sulfonate (EMS). Both trans-anethole and eugenol exerted dose-related antigenotoxic effects against PCB and URE. There was no significant increase in genotoxicity when trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg body weight) were administered alone.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eugenol
/
Aromatizantes
/
Anisóis
/
Mutagênicos
Limite:
Animals
Idioma:
En
Revista:
Food Chem Toxicol
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Índia
País de publicação:
Reino Unido