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Anti-genotoxicity of trans-anethole and eugenol in mice.
Abraham, S K.
Afiliação
  • Abraham SK; School of Life Sciences, Jawaharlal Nehru University, -110067, New Delhi, India. asuresh51@hotmail.com
Food Chem Toxicol ; 39(5): 493-8, 2001 May.
Article em En | MEDLINE | ID: mdl-11313116
The naturally occurring flavouring agents trans-anethole and eugenol were evaluated for antigenotoxic effects in mice. The test doses of trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg weight) were administered by gavage 2 and 20 h before the genotoxins were injected intraperitoneally. Anti-genotoxic effects were assessed in the mouse bone marrow micronucleus test. Pretreatment with trans-anethole and eugenol led to significant antigenotoxic effects against cyclophosphamide (CPH), procarbazine (PCB), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and urethane (URE). In addition, trans-anethole inhibited the genotoxicity of ethyl methane sulfonate (EMS). Both trans-anethole and eugenol exerted dose-related antigenotoxic effects against PCB and URE. There was no significant increase in genotoxicity when trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg body weight) were administered alone.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eugenol / Aromatizantes / Anisóis / Mutagênicos Limite: Animals Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Índia País de publicação: Reino Unido
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eugenol / Aromatizantes / Anisóis / Mutagênicos Limite: Animals Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2001 Tipo de documento: Article País de afiliação: Índia País de publicação: Reino Unido