[The pro-apoptotic factors Fas Ligand and Trail. Molecular mechanisms, physiopathological role and therapeutic potential]. / I fattori pro-apoptotici Fas Ligando e Trail. Meccanismi molecolari, ruolo fisiopatologico e potenzialità terapeutiche.
Minerva Med
; 92(2): 99-111, 2001 Apr.
Article
em It
| MEDLINE
| ID: mdl-11323572
ABSTRACT
Programmed cell death, also known as apoptosis, is a normal physiologic process which occurs during embryonic development as well as in maintenance of tissue homeostasis. Increasing evidence suggests that alterations in cell death contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases and acquired immunodeficiency syndrome (AIDS). The extraordinary research activity of the past few years has resulted in the characterization of the principal proteins involved in the apoptosis machinery. An area of particular interest has been the induction of apoptosis by two death receptor/ligand pairs, Fas/Fas Ligand and DR4-DR5/TRAIL. The identification of these molecules with the recruited signaling pathways could clarify their physiopathological implications, having a significant impact upon potential therapeutic interventions in diseases associated with cell survival alterations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Apoptose
/
Receptores do Fator de Necrose Tumoral
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
It
Revista:
Minerva Med
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Itália