Microvascular development and growth of uterine tissue during the estrous cycle in mares.
Am J Vet Res
; 62(4): 526-30, 2001 Apr.
Article
em En
| MEDLINE
| ID: mdl-11327459
ABSTRACT
OBJECTIVE:
To document uterine growth and microvascular development in the endometrium of uteri with differing degrees of fibrosis as well as uterine growth throughout the estrous cycle of mares. ANIMALS 30 mares. PROCEDURE Uterine tissue was obtained during the breeding season from a slaughter facility. Stage of estrous cycle of the mares was assessed on the basis of ovarian structures and plasma progesterone concentrations. Endometrium was characterized by use of light microscopy, and blood vessel walls were marked by histochemical techniques. Microvascular development was evaluated by a computerized image analysis system. Growth of uterine tissue was based on cellular content of DNA and RNA, RNADNA, and proteinDNA.RESULTS:
Significant differences in vascular density were not observed in the endometrium of uteri obtained from mares euthanatized during the follicular or luteal phase of the estrous cycle, regardless of whether endometrial classification of degree of fibrosis was considered. There was a 3-fold increase in amount of DNA and RNA of endometrial cells in the follicular phase when compared to myometrium. Hypertrophy of endometrial tissue during the luteal phase was reflected by a significant increase in cell protein content and proteinDNA. CONCLUSIONS AND CLINICAL RELEVANCE Endometrial growth of vascular tissues during the estrous cycle may be coordinated with development of nonvascular tissue. Estrogen and progesterone may play a role in regulation of uterine growth and angiogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estro
/
Neovascularização Fisiológica
/
Endométrio
/
Cavalos
Limite:
Animals
Idioma:
En
Revista:
Am J Vet Res
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Portugal