Clinical impact of interlaboratory variation in international normalized ratio determinations.
Am J Health Syst Pharm
; 58(8): 684-8, 2001 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-11329760
ABSTRACT
Variation among laboratories and point-of-care (POC) devices in International Normalized Ratio (INR) determinations for individual patients in the same community was studied. For each patient, blood samples obtained from a single venipuncture followed by a finger stick were tested at three laboratories and with two POC devices. A nonparametric analysis of variance and regression analysis were used to compare INRs across sources. The potential clinical impact of differences between pairs of INR readings (i.e., whether a difference was likely to result in a change in therapy) was evaluated. Complete data were obtained and analyzed for 41 patients. Of the five sources of INRs, results from two laboratories and one POC device were significantly similar. Results from one laboratory and one POC device were significantly different from the other results. Variation between INR readings from two different sources might have resulted in a change in therapy 10-30% of the time. Variations occurred in INR readings among three laboratories and two POC devices and could have led to a substantial number of inappropriate changes in therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Varfarina
/
Laboratórios Hospitalares
/
Sistemas Automatizados de Assistência Junto ao Leito
/
Coeficiente Internacional Normatizado
/
Anticoagulantes
Tipo de estudo:
Evaluation_studies
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Am J Health Syst Pharm
Assunto da revista:
FARMACIA
/
HOSPITAIS
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos