Plasma levels of syndecan-4 (ryudocan) are elevated in patients with acute myocardial infarction.
Thromb Haemost
; 85(5): 793-9, 2001 May.
Article
em En
| MEDLINE
| ID: mdl-11372670
ABSTRACT
Syndecan-4 (ryudocan) is a cell-surface heparan sulfate proteoglycan, which plays an important role in a variety of biological functions including regulation of blood coagulation. cell adhesion, and cell growth. In this study, we measured plasma levels of syndecan-4 in patients with acute myocardial infarction using an enzyme-immunoassay, and found that they were extremely high, with a peak of average (10.5 +/- 5.6 ng/ml, 2 weeks after onset), as compared with those in normal subjects (0.078 +/- 0.030 ng/ml) (p < 0.001). We also observed a distinct expression of syndecan-4 in the repair region of the damaged cardiac tissues with infarction, but not in intact region, by immunohistochemical analysis. To clarify the mechanism of syndecan-4 induction, we investigated the hypoxia effect on its expression, and found that hypoxia treatment up-regulated the gene expression of syndecan-4 in various types of cells. Taken together, it is suggested that syndecan-4 is induced by hypoxia stimuli in ischemic heart tissues, and may function as a tissue-repair molecule via biological mediators such as heparin-binding growth factors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteoglicanas
/
Glicoproteínas de Membrana
/
Infarto do Miocárdio
Tipo de estudo:
Observational_studies
Limite:
Aged80
País/Região como assunto:
Asia
Idioma:
En
Revista:
Thromb Haemost
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão