The development of genomics-derived pharmaceuticals.

ABSTRACT

Messenger RNAs for the large majority of human genes are now available. Most of those contained in the Human Genome Sciences database are capable of producing functional proteins. We have sequenced the clones of approximately 8000 that are believed to be involved in cell signaling, and have produced small amounts of the corresponding proteins. These are being screened for biological activity; four have been entered into clinical trials, with one demonstrating clinical activity thus far.