Methamphetamine increases expression of the apoptotic c-myc and L-myc genes in the mouse brain.
Brain Res Mol Brain Res
; 90(2): 202-4, 2001 Jun 20.
Article
em En
| MEDLINE
| ID: mdl-11406298
ABSTRACT
To clarify the possible mechanisms by which the recreational drug, methamphetamine (METH), induces apoptosis, we investigated its effects on the expression of Myc apoptotic genes. This paper presents the characterization of c-myc and L-myc gene transcription in the striatum and the cortex. In addition, the expression of the corresponding proteins was also evaluated. Our observations reveal that c-myc and L-myc were up-regulated by METH at both the mRNA and protein levels. Thus, myc transcription factors might be responsible for some aspects of METH-induced apoptotic processes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Química Encefálica
/
Proteínas Proto-Oncogênicas c-myc
/
Apoptose
/
Estimulantes do Sistema Nervoso Central
/
Metanfetamina
Limite:
Animals
Idioma:
En
Revista:
Brain Res Mol Brain Res
Assunto da revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos