[Tamoxifen: does a wider range of indications require more careful monitoring?]. / Tamoxifen; ruimere indicaties, uitgebreidere controle?
Ned Tijdschr Geneeskd
; 145(22): 1041-3, 2001 Jun 02.
Article
em Nl
| MEDLINE
| ID: mdl-11414162
ABSTRACT
Two patients, premenopausal women aged 48 years and 37 years, who were treated with tamoxifen following a mammary carcinoma operation, experienced abdominal complaints, hot flushes, vaginal discharge, an irregular menstrual cycle and/or concern about the increased risk of ovarian carcinoma. Transvaginal ultrasonography of the ovaries and laboratory tests indicated ovarian overstimulation. Both patients temporarily stopped using tamoxifen; in one of the patients both ovaries were ablated. The range of indications for treatment with tamoxifen has in recent years been extended to premenopausal patient groups and the length of treatment has been increased from two to five years. We recommend more extensive checks when prescribing tamoxifen to premenopausal patients in view of the possible adverse effects of ovarian stimulation associated with this treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tamoxifeno
/
Neoplasias da Mama
/
Síndrome de Hiperestimulação Ovariana
/
Pré-Menopausa
/
Moduladores Seletivos de Receptor Estrogênico
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
Nl
Revista:
Ned Tijdschr Geneeskd
Ano de publicação:
2001
Tipo de documento:
Article