Myoclonus in epilepsy patients with anticonvulsive add-on therapy with pregabalin.
Epilepsia
; 42(6): 790-2, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11422338
ABSTRACT
PURPOSE:
To report on the occurrence of myoclonus in patients receiving pregabalin (PGB) for the treatment of focal epilepsy.METHODS:
Clinic records of 19 patients who were consecutively enrolled at a tertial referral epilepsy center in a randomized, double-blind and/or open add-on study with PGB were reviewed.RESULTS:
In four patients treated with PGB, focal myoclonus newly developed. The side effect appeared with PGB doses of 50-600 mg/day; the intensity showed some dose dependency. All patients had medically refractory focal epilepsy and received other antiepileptic drugs (AEDs) besides the study medication. One patient showed focal myoclonic jerks of the left arm, whereas the other patients developed multifocal myoclonus. Polygraphic studies including electromyogram (EMG)-triggered back-averaging of the EEG in the patient with the highest frequency of myoclonic jerks showed no visible correlate of the myoclonus. In this patient, frequency and intensity of myoclonic jerks significantly decreased after dose reduction of PGB. In the other cases, myoclonus was only subtle and did not significantly interfere with daily activities, so that a dose reduction of PGB was not considered necessary.CONCLUSIONS:
These data indicate a relatively high incidence (four of 19) of myoclonus associated with PGB therapy. The rate seems to be at least as high as reported in patients receiving the structurally similar anticonvulsant gabapentin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epilepsias Parciais
/
Ácidos Cicloexanocarboxílicos
/
Ácido gama-Aminobutírico
/
Aminas
/
Anticonvulsivantes
/
Mioclonia
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Incidence_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Epilepsia
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Alemanha