Enantiomerically pure cyclopropyl hemiacetals: lipase-catalyzed synthesis of chiral, nonracemic ester homoenolate equivalents.
Org Lett
; 3(2): 189-91, 2001 Jan 25.
Article
em En
| MEDLINE
| ID: mdl-11430031
ABSTRACT
[figure see text] Enantiomerically pure cyclopropyl hemiacetals can be obtained by lipase-catalyzed kinetic resolution of their acylated congeners. It is demonstrated that lipases from Candida antarctica and Pseudomonas cepacia show enantiodivergent behavior toward these substrates. Subsequent ring opening of these building blocks can be achieved with ZnCl2 leading to chiral, nonracemic alpha-substituted homoenolate anions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Alemanha
País de publicação:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA