Pharmacokinetics of antibiotic prophylaxis in major orthopedic surgery and blood-saving techniques.
Orthopedics
; 24(7): 665-9, 2001 Jul.
Article
em En
| MEDLINE
| ID: mdl-11478553
ABSTRACT
The pharmacokinetics of cefuroxime, cefotiam, cefamandole, and ampicillin/sulbactam were randomly measured in 40 patients undergoing major orthopedic surgery associated with high blood and volume turnover and intraoperative blood salvage. Serum and bone concentrations and the pharmacokinetics occurring in the context of these procedures were measured. No changes in elimination half-life relative to a normal population occurred with cefuroxime, cefotiam, and ampicillin. Serum and tissue concentrations were slightly lower with cefamandole and sulbactam, but reapplication of the initial dose was required with all antibiotics 4 hours after the first application.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cefotiam
/
Sulbactam
/
Cefamandol
/
Cefuroxima
/
Cefalosporinas
/
Antibioticoprofilaxia
/
Procedimentos Ortopédicos
/
Quimioterapia Combinada
/
Ampicilina
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Orthopedics
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Alemanha