Haplotype analysis of BRCA2 8765delAG mutation carriers in French Canadian and Yemenite Jewish hereditary breast cancer families.
Hum Hered
; 52(2): 116-20, 2001.
Article
em En
| MEDLINE
| ID: mdl-11512557
ABSTRACT
The BRCA2 8765delAG mutation was previously reported in hereditary breast cancer families of French Canadian and Yemenite Jewish descent. Haplotype analysis, using six microsatellite markers that span BRCA2 and two intragenic polymorphisms, was performed on 8765delAG mutation carriers to determine if there was evidence that the mutations were identical by descent. The alleles of the microsatellite markers most closely flanking BRCA2 (D13S1697 and D13S1701) were found to be identical in state in all the mutation carriers. However, the disease-associated allele of one of the intragenic markers differed between the Yemenite Jews and French Canadian families, indicating that the 8765delAG mutation has independent origins in these two geographically and ethnically distinct populations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Haplótipos
/
Neoplasias da Mama
/
Judeus
/
Mutação
/
Proteínas de Neoplasias
Limite:
Female
/
Humans
País/Região como assunto:
America do norte
/
Europa
Idioma:
En
Revista:
Hum Hered
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Canadá