Behavioral and neuroendocrine actions of endomorphin-2.
Peptides
; 22(9): 1459-63, 2001 Sep.
Article
em En
| MEDLINE
| ID: mdl-11514029
The effects of intracerebroventricularly administered endomorphin-2 (EM2) on open-field activity and the hypothalamo-pituitary-adrenal (HPA) system were investigated. EM2 (0.25-1 microg) significantly increased both the locomotor and the rearing activity, resulting in a bell-shaped dose-response curve. EM2 also enhanced corticosterone release, with an even more profound downturn phase at higher concentrations. The corticotropin-releasing hormone (CRH) antagonist alpha-helical CRH9-41 completely abolished the EM2-evoked endocrine and behavioral responses. These findings reinforce the hypothesis that the endomorphins may play a significant role in the regulation of locomotion, rearing activity and the HPA system through the release of CRH.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Fragmentos de Peptídeos
/
Hormônio Liberador da Corticotropina
/
Analgésicos Opioides
/
Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Hungria
País de publicação:
Estados Unidos