Two new loci affecting cell division identified as suppressors of an ftsQ-null mutation in Streptomyces coelicolor A3(2).
FEMS Microbiol Lett
; 202(2): 251-6, 2001 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-11520623
ABSTRACT
Mutations in fts genes partially or completely block both vegetative cell division and sporulation septation in the filamentous bacterium Streptomyces coelicolor A3(2). Using a novel screen, we independently isolated two double-mutant strains, each containing a spontaneous suppressor mutation, which partially restores division to an ftsQ-null mutant. Genetic complementation experiments revealed that the suppressor mutations alone confer no observable defect in sporulation. The suppressor mutations were genetically mapped to regions of the chromosome, distinct from each other and the division and cell wall cluster containing ftsQ. Therefore, the genes identified by the suppressor mutations were named sqnA and sqnB (suppressor of ftsQ-null) and may be representatives of a novel class of genes involved in cell division or the regulation of cell division in this mycelial organism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Proteínas de Bactérias
/
Proteínas de Escherichia coli
/
Genes Bacterianos
/
Proteínas de Membrana
Idioma:
En
Revista:
FEMS Microbiol Lett
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos